List of potential nanoparticle candidates
CORE
• Small molecules
• Protein/Peptides
• Biologics/Antibodies
• DNA/RNA
• Other inorganic materials
• Aluminum oxide (Al2O3)
• Antimony oxide (Sb2O3)
• Barium titanate (BaTiO3)
• Bismuth, Bismuth oxide (Bi, BiO)
• Carbon-dot (C-dot)
• Cerium dioxide (CeO2, ceria, cerium(IV) oxide, ceric oxide, ceric dioxide, cerium oxide or cerium dioxide)
• Cobalt oxide (Co3O4, cobalt(II,III) oxide)
• Copper/Copper oxide (Cu, CuO)
• Gold (Au)
• Holmium oxide (HoO)
• Indium oxide (In2O3)• Iridium / Iridium oxide (Ir, IrO2)
• Iron oxide (Fe3O4, iron(II,III) oxide, magnetite, Fe2O3, iron(III) oxide-hydroxide, FeOOH, iron oxyhydroxide)
• Lithium oxide (Li2O, lithia)
• Lanthanum oxide (La2O3, lanthana)
• Nickel / Nickel oxide (Ni, NiO)
• Niobium oxide (Niobium pentoxide, columbium oxide, Nb2O5)
• Palladium (Pd)
• Platinum / Platinum dioxide (Pt, PtO2)
• Silica (SiO2, silicon dioxide)
• Silver (Ag)
• Titanium dioxide (titanium(IV) oxide or titania, TiO2, anatase)
• Tin oxide (SnO2)
• Tungsten carbide (WC)
• Yttrium oxide (Y2O3, Yttria)
• Zinc oxide (ZnO)
• Zirconium dioxide (ZrO2, zirconia)
ENCAPSULATION
• PLGA (Poly(lactic-co-glycolic acid))
• PLA (Polylactic acid)
• PCL (Polycaprolactone)
• PEG (Polyethylene glycol)
• PVP (Polyvinylpyrrolidone)
• Chitosan
• Gelatin Albumin (e.g., HSA)
• Dextran Polysorbate 80 (Tween 80)
• Liposome (Phospholipid-based)
• Solid Lipid Nanoparticles (SLNs)
• Nanostructured Lipid Carriers (NLCs)
• Dendrimers (e.g., PAMAM)
• Cyclodextrins
• Polypeptides (e.g., poly-L-lysine)
• Hyaluronic Acid (HA)
• Poly(β-amino esters)
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Dedication on nanomedicine since 2011
Multiple world’s 1st publications on the therapeutic efficacy of nanomedicine
2012
Angewandte Chemie
Ceria Nanoparticles that can Protect against Ischemic Stroke
(IF : 16.1)
2017
Nano Research
Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage
(IF : 9.6)
2017
Angewandte Chemie
Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment
(IF : 16.1)
2019
Advanced Healthcare Materials
Ceria Nanoparticles Fabricated with 6-Aminohexanoic Acid that Overcome Systemic Inflammatory Response Syndrome
(IF : 10.0)
2018
Stroke
Ceria Nanoparticles Synthesized With Aminocaproic Acid for the Treatment of Subarachnoid Hemorrhage
(IF : 7.9)
2022
Nanomedicine
Ultrasmall polymer-coated cerium oxide nanoparticles as a traumatic brain injury therapy
(IF : 4.2)
20+ Research articles & 10+ National and International patent registration
Research articles
•Nanomedicine: Nanotechnology, Biology and Medicine 2022, 45, 102586
•Chemistry of Materials 2022, 34 (10), 4437–4445
•ACS Biomaterials Science & Engineering 2021, 7 (9), 4446–4453
•Biomaterials 2020, 239, 119859
•ACS Nano 2020, 14 (2), 2483-2496
•ACS Applied Bio Materials 2019, 2 (8), 3630–3638
•Advanced Healthcare Materials 2019, 8 (9), 1801548
•Korean Journal of Chemical Engineering 2019, 36 (1), 157–165
•Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2018, e1515
•Stroke 2018, 49, 3030–3038
•Nano Research 2018, 11 (7), 3582–3592
•ACS Applied Nano Materials 2018, 1 (4), 1940–1948
•ACS Central Science 2018, 4(4), 484–492
•ACS Applied Materials & Interfaces 2017, 9 (37), 31372–31380
•Chemistry of Materials 2017, 29 (16), 6883–6892
•Nano Letters 2017, 17 (5), 2747–2756
•Journal of Nanoscience and Nanotechnology 2016, 16 (7), 6942–6948
•ACS Applied Materials & Interfaces 2016, 8 (1), 449–454
•Materials Research Bulletin 2015, 70, 424–429
•ChemSusChem 2014, 7 (12), 3452–3458
Patents
•10-1732641, Pharmaceutical composition for treating intracerebral hemorrhage comprising ceria …
•10-1754798, Cytokine supported porous silica nanoparticle containing M2 …
•10-1762825, Cytokine supported porous silica nanoparticle containing inflammation…
•10-1782622, Ceria nanoparticle for biomedical treatment and pharmaceutical composition including …
•10-1915777,Ceria nanocomposite comprising ceria nanoparticles for treating SAH…
•(US) 11,246,944, Ceria nanocomposite for biomedical treatment..
•(US) 11,123,301,Ceria nanocomposite comprising ceria nanoparticle for treating subarachnoid hemorrhage…
•PCT/KR2021/003737, Novel cerium oxide nanocomposite and use thereof
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Sample application models of nanoparticles
Ce NPs
Nanomedicine CDMO Case Highlights
Manufacturing case
has developed world’s first FDA IND approved anti-inflammatory nanomedicines for acute AND chronic diseases (from critical to degenerative conditions). This cerium oxide cored nanomedicine is developed with INNOSUFRACE® platform technology and has both therapeutic function and biocompatibility. Our experience covers the entire cycle from R&D to manufacturing for clinical trials.
OmniParticles
1st Ce NP approved by FDA for clinical trials
(Phase 1 trial to start)
INNOSURFACE®
Platform Technology
1st polymer
-coating
2nd polymer
-coating
CeCe³⁺
for
biocompatibility
for
targetability
Cerium
precursor
Cerium oxide :
1st polymer layer
directly incorporated
Cerium oxide nanozyme :
2 polymers
incorporated
Application :
• Nanozyme incorporated with biocompatible polymers
• Synthesis of cerium oxide nanoparticles via INNOSURFACE® platform technology
• Multi-layered polymer coating
Au NPs
Application:
Sphere
Rod
Hydrophilic
•Hyperthermia
•Solar cell
Lipophilic
•Diagnosis
FeO NPs
Sphere
heat decomposition
Assembly
Needle
Application:
•DDS carrier
Application
•Reactive in magnetic filed
•3D scaffold
Ag NPs
Sphere
Hydrophilic
Wire
Precipitation/polyol process
Lipophilic
Application :
PCB conductive pattern
SiO₂ – DDS Carrier
Nanoparticles combination
Further
combination
Agent
delivery
Able to deliver
• Antigen
• Growth factor
• DNA
•Diagnostic agent